Paper Towns mostly takes place in Orlando, Florida. The setting is described in a way any teenager would talk about growing up in their home town: They find it boring and look forward to making there own fun or trouble. Q, or Quentin, is a bit obsessed with fellow classmate and neighbor Margo Roth Speigelman. A girl who Q and friends are finding to be more of a mystery by the day.
The story is about realizing you never really know a person, you just think you do. The plot's similar to another of John Green's books, Looking For Alaska, but done in a different light - as more of a quest, where Alaska was about a learning experience. To find the mystery that is Margo, Q goes on a scavenger hunt. Literally, and you can follow the clues along with Q to find Margo. I think the characters and setting feel pretty natural and will sit well with teens.
This is a book not just for teens, though. It will be enjoyable for adults as well. There are some strong language and sexuality explicit scenes, but not as bad a as Looking for Alaska. It is a book with a lot of humor, mystery and intrigue. I highly recommend it.